Tien M.H. Ng, PharmD, FHFSA, FCCP, BCPS (AQ Cardiology), FACC
Associate ProfessorClinical Pharmacy
- Heart failure pharmacotherapy
- Heart failure pathophysiology (neurohormonal activation and inflammatory cytokine expression)
- Drug-induced QT prolongation
- USC School of Pharmacy
1985 Zonal Ave.
Los Angeles, CA 90033
Cardiovascular pathophysiology and pharmacotherapy, with a special interest in heart failure. Currently, lead investigator on clinical studies evaluating the influence of hyponatremia on acute heart failure diuretic response, and a prospective trial evaluating the role of vasopressin receptor antagonists as an alternative to conventional diuretics. Collaborating with the Division of Cardiovascular Medicine on clinical studies related to the pharmacologic treatment of heart failure.
Have also conducted research investigating the relationship between pro- and anti-inflammatory cytokine production and adrenergic activation in monocytes of heart failure patients. In heart failure a paradox exists as both catecholamines and inflammatory cytokine expression are elevated, which suggests that the negative feedback mechanism of adrenergic activation exerting an anti-inflammatory effect may be impaired. Impairment of this counter-regulatory mechanism may contribute to the vicious cycle of neurohormonal activation and inflammation leading to disease progression. The goal of these investigations are to characterize the impairment in sympathetic regulation of pro-inflammatory cytokines in heart failure and examine the potential differences in immunomodulatory effects of beta- and alpha-receptor antagonists.
Dr. Ng completed a BS Pharmacy in 1994 from Dalhousie University in Halifax (Canada), a PharmD in 1998 from Wayne State University (Detroit) and a Cardiovascular Pharmacotherapy Fellowship in 2000 from the University of Utah (Salt Lake City). He has been a board certified pharmacotherapy specialist since 2001. Prior to joining USC in March 2004, Dr. Ng was an assistant professor at the University of Nebraska Medical Center. He was the recipient of the Heart Failure Society of America Clinical/Integrative Physiology New Investigator Award in 2002.