Biotechnology Research Team

The USC School of Pharmacy’s biotechnology therapeutics and diagnostics research team focuses on drug design, development and delivery, seeking breakthroughs that will transform tomorrow’s medicine by generating new drug compounds and advances in molecular targeting. From bench to bedside, this research aims to develop cost-effective therapeutics and diagnostics to save and improve lives in the following ways:

  • Drug design: Finding novel compounds that are easier to administer and that more effectively deliver desired therapeutic outcomes
  • Development: Discovering new diagnostic tools that enable more accurate detection of early-stage disease
  • Delivery: Creating cost-effective therapeutics and diagnostics with life-saving and life-enhancing properties that are faster, safer and more effective

Drug Design and Discovery

Finding new ways to design pharmaceutical agents with higher potency and fewer side effects through collaborative, multidisciplinary research

The School’s collaborative, multidisciplinary research—involving chemists, biologists, engineers and clinicians—continues to produce innovative approaches to the design of new drugs with higher effectiveness and fewer side effects. Using advanced technologies, the biotechnology drug design and discovery group identifies pharmaceutical targets and develops new drug candidates to affect those targets. Their work has led to rapid developments in computational biopharmaceutics, protein homology modeling, high-throughput docking methodologies, and the development of new methods for detailed prediction of the structure of biological interfaces. Another major focus is identification and biosynthesis of natural products using “green” production methods that eliminate the need for large amounts of expensive and hazardous organic solvents.

USC Pharmacy experts:
James Adams, PhD
Julio Camarero, PhD
Ian Haworth, PhD
Stan Louie, PharmD
Bogdan Olenyuk, PhD
Clay Wang, PhD
Walter Wolf, PhD

Drug Delivery

Offering a one-of-a-kind program that seeks to design strategies for overcoming the barriers to cellular drug uptake and trafficking

The biotechnology team’s drug delivery group focuses on drug targeting, transport and delivery, with a core of investigators who combine expertise to overcome the barriers to effective drug targeting and cellular uptake. These strategies include: regulation of cellular transport, regulation of membrane trafficking, regulation of protein sorting at cellular membranes, lipidization of peptides to facilitate cellular uptake, and modification of proteins using PTD domains. Monitoring drug distribution using non-invasive techniques, such as magnetic resonance, is a further strength of the program and includes the development of new methods for the measurement of drug pharmacokinetics in vivo.

USC Pharmacy experts:
Sarah Hamm-Alvarez, PhD
Andrew MacKay, PhD
Curtis Okamoto, PhD
Wei-Chiang Shen, PhD
Jennica L. Zaro, PhD