Jean C. Shih

Jean C. Shih, PhD

University Professor
Boyd & Elsie Welin Professor

Pharmacology and Pharmaceutical Sciences

Research Topics

  1. Neurobiology of Emotion
  2. Autism and brain developmental disorders
  3. MAO as Noval target for Cancer Therapeutics
  4. Gene regulation and functions
  5. Drug discovery and development

Contact Information

Education

BS 1964 Biochemistry - National Taiwan University, Taiwan
PhD 1968 Biochemistry - University of California, Riverside

Postdoctoral Research Fellowship:
1968 - 1970 University of California, Los Angeles

Jean C. Shih

Research Interest

Research objectives in Shih Lab are to understand the roles of neurotransmitters on gene expression, signal transduction behaviors and ultimately diseases. They are studying the role of serotonin and dopamine in neuronal development, regulation of transcription factors in a series of monoamine oxidase (MAO) gene knock-out mice, which are animal models for anxiety, aggression and autistic-like-behavior and aggression. Recently, they showed these gene knockout mice also slowed down the progression and metastasis of prostate and brain cancers Thus provides unique animal models to study the interaction between tumors and microenvironment. Currently, Shih Lab used these KO mice model to develop novel targets for the treatment and early diagnosis of autistic-like behaviors and prostate and brain cancer.

Biography

Dr. Shih received her B.S. in biochemistry from the National Taiwan University, where she graduated as the valedictorian. She earned her Ph.D. in biochemistry from a joint program at the University of California, Riverside (UCR) and Los Angeles (UCLA). Dr. Shih continued as a postdoctoral research fellow at UCLA and, in 1974, she joined the School of Pharmacy faculty at USC.

She is currently a University Professor and holds the Boyd and Elsie Welin endowed chair. She has received numerous honors: She received two Research Scientist Awards and two MERIT awards from the National Institutes of Health (NIH), each providing a 10-year support to investigators whose research competence and productivity are distinctly superior and who are likely to continue to perform in an outstanding manner. The MERIT award is given to the top 1% investigators of the country. She is a Fellow of Academia Sinica, Taiwan; Fellow of the American College of Neuropsychopharmacology; a recipient of the Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy (AACP); USC Associates Award for Creativity in Research and Scholarship; among many others. A Distinguish Series Kaiser Lecturer at University of Hawaii.

Dr. Shih is a member of the NIH study sections (Psycho Clinical Biology, 1984-88; Neurobiology, 1990-94; NICHD Mental Retardation Committee, 1997-2001). She is also a member of the International Brain Research Committee of the National Academy of Sciences (1995-2000). She is a current member and past president of the Society of Chinese Bioscientists in America (2002-2004). She is a mentor of American. NIH Director and Pioneer Award review committee (2011-2014).

She is the founding Director of Center for USC–Taiwan Translational Research. Center scientists are exploring new cancer therapies that target monoamine oxidase using a collaborative approach among Pacific Rim partners. At the 15th International Symposium of the Society of Chinese Bioscientists in America (SCBA) held on June 28, 2015 in Taipei, Taiwan, she co-chaired a session focusing on promising new leads in the fight against cancer, autism and cardiovascular diseases aiming to develop pharmaceuticals that target monoamine oxidase (MAO), a key enzyme that regulates brain function and may be linked to cancer risk.
http://pharmacyschool.usc.edu/news/usc-taiwan-translational-research-center-hosts-session-at-international-symposium-in-taipei/

Selected Projects/Publications

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Monoamine oxidase A inhibitor-near-infrared dye conjugate reduces prostate tumor growth.   Wu JB, Lin TP, Gallagher JD, Kushal S, Chung LW, Zhau HE, Olenyuk BZ, Shih JC.  J Am Chem Soc. 2015 Feb 18;137(6):2366-74. doi: 10.1021/ja512613j. Epub 2015 Jan 27.  PMID: 25585152

PubMed -Link

Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis.  Boyang Wu J, Shao C, Li X, Li Q, Hu P, Shi C, Li Y, Chen Y, Yin F, Liao C, Stiles BL, Zhau HE, Shih JC, Chung LWK.  J Clin Invest. 2014 Jul;124(7):2891-908. doi: 10.1172/JCI70982. Epub 2014 May 27.  PMID: 24865426

PubMed -Link

Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice.  Bortolato M, Godar SC, Tambaro S, Li FG, Devoto P, Coba MP, Chen K, Shih JC.  Neuropharmacology. 2013 Dec;75:223-32. doi: 10.1016/j.neuropharm.2013.07.003. Epub 2013 Jul 16.  PMID: 23871843   [PubMed - in process]

PubMed -Link

Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.  Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, Shih JC. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12816-21. doi: 10.1073/pnas.1308037110. Epub 2013 Jul 15.  PMID:  23858446    [PubMed - indexed for MEDLINE] 

PubMed -Link

Monoamine oxidase A and A/B knockout mice display autistic-like features.  Bortolato M, Godar SC, Alzghoul L, Zhang J, Darling RD, Simpson KL, Bini V, Chen K, Wellman CL, Lin RC, Shih JC.  Int J Neuropsychopharmacol. 2013 May;16(4):869-88. doi: 10.1017/S1461145712000715. Epub 2012 Jul 31.  PMID:  22850464   [PubMed - indexed for MEDLINE] 

PubMed -Link

NMDARs mediate the role of monoamine oxidase A in pathological aggression.  Bortolato M, Godar SC, Melis M, Soggiu A, Roncada P, Casu A, Flore G, Chen K, Frau R, Urbani A, Castelli MP, Devoto P, Shih JC.  J Neurosci. 2012 Jun 20;32(25):8574-82. doi: 10.1523/JNEUROSCI.0225-12.2012.  PMID:  22723698  [PubMed - indexed for MEDLINE] 

PubMed -Link

Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence.  Bortolato M, Shih JC.  Int Rev Neurobiol. 2011;100:13-42. doi: 10.1016/B978-0-12-386467-3.00002-9. Review.  PMID:  21971001   [PubMed - indexed for MEDLINE] 

PubMed -Link

Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice.  Bortolato M, Chen K, Godar SC, Chen G, Wu W, Rebrin I, Farrell MR, Scott AL, Wellman CL, Shih JC.  Neuropsychopharmacology. 2011 Dec;36(13):2674-88. doi: 10.1038/npp.2011.157. Epub 2011 Aug 10.  PMID:  21832987   [PubMed - indexed for MEDLINE] 

PubMed -Link

Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation.  Wu JB, Shih JC.  Mol Pharmacol. 2011 Oct;80(4):714-23. doi: 10.1124/mol.111.072744. Epub 2011 Jul 20.  PMID:  21775495  [PubMed - indexed for MEDLINE] 

PubMed -Link

Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells.  Wang ZQ, Chen K, Ying QL, Li P, Shih JC.  J Neural Transm. 2011 Jul;118(7):997-1001. doi: 10.1007/s00702-011-0655-0. Epub 2011 May 24.  PMID:  21607742  [PubMed - indexed for MEDLINE] 

PubMed -Link

Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B.  Chen K, Ou XM, Wu JB, Shih JC.  Mol Pharmacol. 2011 Feb;79(2):308-17. doi: 10.1124/mol.110.067439. Epub 2010 Oct 27.  PMID:  20980443  [PubMed - indexed for MEDLINE] 

PubMed -Link

Regulation of monoamine oxidase A by the SRY gene on the Y chromosome.  Wu JB, Chen K, Li Y, Lau YF, Shih JC.  FASEB J. 2009 Nov;23(11):4029-38. doi: 10.1096/fj.09-139097. Epub 2009 Aug 6.  PMID:  19661285  [PubMed - indexed for MEDLINE] 

PubMed -Link